“Extremely critical” fire weather conditions are forecast to impact a large part of Southern California, with the strongest Santa Ana wind event of the year possibly occurring Wednesday before some improvement Friday. Affected areas include the entire Los Angeles metro area, where the Getty Fire continues to burn. Wind gusts at or above 70 mph in higher elevations coupled with very dry air (relative humidity less than 10%) will make it incredibly difficult to make any progress towards containing this fire, and presents a high risk for new fires to start.
Weather Prediction Center surface forecast for 5AM PDT Wednesday 
Weather Prediction Center surface forecast for 5PM PDT Thursday
Synoptic Set Up
Believe it or not, the strength of the Santa Ana winds will be tied directly to the very cold air mass moving into the Great Basin. A low along the leading edge of this cold air has caused a massive ongoing snowstorm across much of Colorado. Behind this, cold, stable air will move in along with a strong area of high pressure with surface pressures forecast above 1040 mb. At the same time, a coastal low will sweep south along the northern and central CA coast along the leading edge of the colder air accompanying this high pressure. This will set up a tight pressure gradient at the coast favoring strong offshore east-northeast winds, with local forecast offices citing model output of as much as 10-12 mb gradient from Barstow to LAX, over a distance of only 200 miles.
Impacts
With the tight pressure gradient forecast above, forecasters are calling for the possibility of gusts in excess of 70 mph in the mountain ranges near the coast with, with lower wind gusts of 35-40 mph at lower elevations. The influx of cold air already less capable of holding moisture that will downslope off coastal ranges and towards the ocean will yield relative humidities of 3-8% (as the air dries further during downsloping due to compressional warming). Santa Ana winds of this magnitude along with such dry conditions easily warrant the Storm Prediction Center designation of extremely critical fire weather.
GFS model output forecast sounding for KLAX at 11AM PDT Wednesday. Note the huge gap between the green dew point line and red environmental temperature line at the surface (5°F dew point, 64°F temperature). This will result in extremely low relative humidity values. 
Storm Prediction Center fire weather outlook for Wednesday
Timing
Peak potential for winds appears to be during the overnight hours through morning and early afternoon Wednesday. This is the time when the pressure gradient will be maximized. The high pressure referenced above is forecast to weaken overnight into Thursday, while the coastal low should also dissipate. The high pressure is forecast to continue weakening into the weekend, thus ending the most dangerous period of fire weather.